Attraction
21. Cusco Cathedral
The Renaissance cathedral on the north-east side of the Plaza de Armas, built on an Inca palace and filled with Cusco School paintings and carved altars.
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22. Escadaria Selarón
A 215-step staircase between Lapa and Santa Teresa covered in more than 2,000 tiles by the Chilean artist Jorge Selarón between 1990 and 2013.
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23. Jardín Botánico de Medellín
A 13.2 hectare botanical garden opened in 1972 in northern Medellín, with more than 1,000 living species, the timber Orquideorama, a butterfly house and a lagoon.
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24. Museo Botero
A free museum in a colonial mansion holding more than 200 works donated by Fernando Botero, from his own paintings to pieces by Picasso, Monet and Dalí.
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25. Museo Chileno de Arte Precolombino
A museum of pre-Columbian art in the 1807 Royal Customs House, a block from the Plaza de Armas, covering some 10,000 years and around 100 American cultures.
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26. Palacio de la Inquisición (Museo Histórico de Cartagena)
A white colonial palace on Plaza de Bolívar that housed the Holy Office tribunal until 1821 and is now the Museo Histórico de Cartagena.
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27. Pinacoteca de São Paulo
The city's oldest art museum, founded in 1905 in an exposed-brick building beside the Jardim da Luz, with more than 12,000 works centred on Brazilian art.
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28. Cartagena Cathedral (Catedral de Santa Catalina de Alejandría)
Cartagena's 16th-century stone cathedral beside Parque de Bolívar, damaged by Francis Drake's cannon in 1586 and crowned by a tower remodelled in 1908.
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29. Lima Cathedral
The cathedral on the east side of the Plaza Mayor, rebuilt several times after earthquakes, holds the tomb of Francisco Pizarro and a museum of colonial religious art.
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30. Metropolitan Cathedral of Buenos Aires
Buenos Aires' neoclassical cathedral on Plaza de Mayo, home to the mausoleum of General José de San Martín and linked to Pope Francis.
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31. Museu do Amanhã (Museum of Tomorrow)
Santiago Calatrava's science museum on Pier Mauá, opened in 2015, with a multimedia exhibition on the cosmos, the Earth and humanity's future.
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32. Parque Explora
An interactive science museum opened in 2008 in northern Medellín, with more than 300 hands-on exhibits, a large aquarium, a vivarium and a planetarium.
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33. Plaza de Armas
Santiago's founding square, laid out in 1541, framed by the Metropolitan Cathedral, the Central Post Office, the National History Museum and the city hall.
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34. Plaza de Armas
Cusco's main square, the Inca Huacaypata, framed by the Cathedral, the Compañía church and colonial arcades built over Inca palaces.
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35. Plaza de Bolívar
Bogotá's main square, framed by the cathedral, the National Capitol, the Palace of Justice and the mayor's office, with Tenerani's 1846 statue of Bolívar at its centre.
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36. Theatro Municipal de São Paulo
An opera house from 1911 modelled on the Palais Garnier, home to the city's symphony orchestra and ballet and the venue of the 1922 Modern Art Week.
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37. Catedral da Sé
São Paulo's neo-Gothic cathedral on Praça da Sé, built between 1913 and 1967, with 92-metre spires, a Florentine-style dome and a crypt of the city's bishops.
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38. Cerro Santa Lucía
A small rocky hill in the city centre where Santiago's story began, turned into a park of terraces, fountains, stairways and viewpoints in the 1870s.
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39. Huaca Pucllana
A large adobe pyramid built by the Lima culture between about AD 200 and 700, preserved in the middle of Miraflores with a small site museum and guided tours.
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40. Iglesia de la Compañía de Jesús
The Jesuit church on the Plaza de Armas, rebuilt after the 1650 earthquake with a Baroque stone facade and a gilded cedar altarpiece over 20 metres high.
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